'Lifeless' prion proteins are 'capable of evolution'

BBC

Scientists have shown for the first time that "lifeless" prion proteins, devoid of all genetic material, can evolve just like higher forms of life.

The Scripps Research Institute in the US says the prions can change to suit their environment and go on to develop drug resistance.

Prions are associated with 20 different brain diseases in humans and animals.

The scientists say their work suggests new approaches might be necessary to develop therapies for these diseases.

In the study, published in the journal Science, the scientists transferred prion populations from brain cells to other cells in culture and observed the prions that adapted to the new cellular environment out-competed their brain-adapted counterparts.

When returned to the brain cells, the brain-adapted prions again took over the population..........